Article
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
Brain research - 27 Jul 2012
Hunter Jesse M, Cirrito John R, Restivo Jessica L, Kinley Robert D, Sullivan Patrick M, Holtzman David M, Koger Deanna, Delong Cynthia, Lin Suizhen, Zhao Lingzhi, Liu Feng, Bales Kelly, Paul Steven M
Abstract excerpt
The apolipoprotein ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and is associated with earlier age of onset. The incidence of spontaneous seizures has been reported to be increased in sporadic AD as well as in the early onset autosomal dominant forms of AD. We now report the emergence of a seizure phenotype in aged apolipoprotein E4 (apoE4) targeted replacement (TR) mice...
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