Synergistic Effect between the APOE ε4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease.

doi:10.3390/ijms251810228

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Article

Synergistic Effect between the APOE ε4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease.

International journal of molecular sciences - 23 Sept 2024

Toral-Rios Danira, Pichardo-Rojas Pavel, Ruiz-Sánchez Elizabeth, Rosas-Carrasco Óscar, Carvajal-García Rosa, Gálvez-Coutiño Dey Carol, Martínez-Rodríguez Nancy Lucero, Rubio-Chávez Ana Daniela, Alcántara-Flores Myr, López-Ramírez Arely, Martínez-Rosas Alma Rosa, Ruiz-Chow Ángel Alberto, Alonso-Vanegas Mario, Campos-Peña Victoria

Abstract excerpt

Temporal Lobe Epilepsy (TLE) is a chronic neurological disorder characterized by recurrent focal seizures originating in the temporal lobe. Despite the variety of antiseizure drugs currently available to treat TLE, about 30% of cases continue to have seizures. The etiology of TLE is complex and multifactorial. Increasing evidence indicates that Alzheimer's disease (AD) and drug-resistant TLE present common...

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PMID: 39337715
DOI: 10.3390/ijms251810228
PMCID: PMC11432663

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