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Article

Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate.

Structure (London, England : 1993) - 3 Jul 2012

Yamaguchi Masaya, Noda Nobuo N, Yamamoto Hayashi, Shima Takayuki, Kumeta Hiroyuki, Kobashigawa Yoshihiro, Akada Rinji, Ohsumi Yoshinori, Inagaki Fuyuhiko

Abstract excerpt

The Atg12-Atg5 conjugate, which is formed by an ubiquitin-like conjugation system, is essential to autophagosome formation, a central event in autophagy. Despite its importance, the molecular mechanism of the Atg12-Atg5 conjugate formation has not been elucidated. Here, we report the solution and crystal structures of Atg10 and Atg5 homologs from Kluyveromyces marxianus (Km), a thermotolerant yeast. KmAtg10...

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Identifiers

PMID: 22682742
DOI: 10.1016/j.str.2012.04.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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