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Article

Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease.

Neurobiology of disease - 1 Jul 2021

Peters Owen M, Weiss Alexandra, Metterville Jake, Song Lina, Logan Robert, Smith Gaynor A, Schwarzschild Michael A, Mueller Christian, Brown Robert H, Freeman Marc

Abstract excerpt

Parkinson's disease (PD) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. Though loss of dopaminergic neuron cell bodies from the substantia nigra pars compacta is a well-studied feature, atrophy and loss of their axons within the nigrostriatal tract is also emerging as an early event in disease progression. Genes that...

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Identifiers

PMID: 33892050
DOI: 10.1016/j.nbd.2021.105368
PMCID: PMC8292971

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