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Article

Clinical severity of Huntington's disease does not always correlate with neuropathologic stage.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2012

Pillai Jagan A, Hansen Lawrence A, Masliah Eliezer, Goldstein Jody L, Edland Steven D, Corey-Bloom Jody

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a triplet-repeat, CAG expansion mutation. Although CAG repeat length is thought to correlate with pathologic burden and disease severity, considerable variability in clinical phenotype remains. This study examined whether neuropathologic burden at autopsy corresponded with severity of clinical phenotype in HD. The brains of 24 patients...

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Identifiers

PMID: 22674458
DOI: 10.1002/mds.25026
PMCID: PMC3412903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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