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Article

Cognitive phenotype and neurodegeneration associated with Tau in Huntington's disease.

Annals of clinical and translational neurology - 1 May 2024

Martinez-Horta Saul, Perez-Perez Jesús, Perez-Gonzalez Rocío, Sampedro Frederic, Horta-Barba Andrea, Campolongo Antonia, Rivas-Asensio Elisa, Puig-Davi Arnau, Pagonabarraga Javier, Kulisevsky Jaime

Abstract excerpt

OBJECTIVE: The clinical phenotype of Huntington's disease (HD) can be very heterogeneous between patients, even when they share equivalent CAG repeat length, age, or disease burden. This heterogeneity is especially evident in terms of the cognitive profile and related brain changes. To shed light on the mechanisms participating in this heterogeneity, the present study delves into the association between Tau...

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PMID: 38544341
DOI: 10.1002/acn3.52031
PMCID: PMC11093246

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