Article
A biological classification of Huntington's disease: the Integrated Staging System.
The Lancet. Neurology - 1 Jul 2022
Tabrizi Sarah J, Schobel Scott, Gantman Emily C, Mansbach Alexandra, Borowsky Beth, Konstantinova Pavlina, Mestre Tiago A, Panagoulias Jennifer, Ross Christopher A, Zauderer Maurice, Mullin Ariana P, Romero Klaus, Sivakumaran Sudhir, Turner Emily C, Long Jeffrey D, Sampaio Cristina
Abstract excerpt
The current research paradigm for Huntington's disease is based on participants with overt clinical phenotypes and does not address its pathophysiology nor the biomarker changes that can precede by decades the functional decline. We have generated a new research framework to standardise clinical research and enable interventional studies earlier in the disease course. The Huntington's Disease Integrated Staging...
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