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Article

Influence of KRAS mutation status in metachronous and synchronous metastatic colorectal adenocarcinoma.

Cancer - 15 Dec 2012

Rose Jeffrey S, Serna Derek S, Martin Ludmila Katherine, Li Xiaobai, Weatherby Lynn M, Abdel-Misih Sherif, Zhao Weiqiang, Bekaii-Saab Tanios

Abstract excerpt

BACKGROUND: Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) are present in approximately 30% to 40% of colorectal adenocarcinomas. Wild-type (WT) KRAS mutation status is predictive of tumor response with epidermal growth factor receptor-directed therapies, but the results from studies evaluating the prognostic value of KRAS status in localized disease have been contradictory. The...

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Identifiers

PMID: 22674181
DOI: 10.1002/cncr.27666
PMCID: PMC3839285

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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