Article
eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension.
The pharmacogenomics journal - 1 Feb 2010
Sandrim V C, Palei A C T, Luizon M R, Izidoro-Toledo T C, Cavalli R C, Tanus-Santos J E
Abstract excerpt
Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the therapeutic responses of women with gestational hypertension (GH) or preeclampsia (PE). We studied 304 hypertensive pregnant women (152 GH and 152 PE), who were stratified according to clinical and laboratorial parameters of therapeutic...
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