Article
Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2012
Foster Steven S, De Saurav, Johnson Linda K, Petrini John H J, Stracker Travis H
Abstract excerpt
The DNA damage response comprises DNA repair, cell-cycle checkpoint control, and DNA damage-induced apoptosis that collectively promote genomic integrity and suppress tumorigenesis. Previously, we have shown that the Chk2 kinase functions independently of the Mre11 complex (Mre11, Rad50, and Nbs1) and ATM in apoptosis and suppresses tumorigenesis resulting from hypomorphic alleles of Mre11 or Nbs1. Based on this...
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