Article
Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia.
Molecular medicine (Cambridge, Mass.) - 7 Sept 2012
Kästner Anne, Grube Sabrina, El-Kordi Ahmed, Stepniak Beata, Friedrichs Heidi, Sargin Derya, Schwitulla Judith, Begemann Martin, Giegling Ina, Miskowiak Kamilla W, Sperling Swetlana, Hannke Kathrin, Ramin Anna, Heinrich Ralf, Gefeller Olaf, Nave Klaus-Armin, Rujescu Dan, Ehrenreich Hannelore
Abstract excerpt
Erythropoietin (EPO) improves cognitive performance in clinical studies and rodent experiments. We hypothesized that an intrinsic role of EPO for cognition exists, with particular relevance in situations of cognitive decline, which is reflected by associations of EPO and EPO receptor (EPOR) genotypes with cognitive functions. To prove this hypothesis, schizophrenic patients (N > 1000) were genotyped for 5'...
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