Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users.

doi:10.1038/npp.2012.92

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Article

Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2012

Schacht Joseph P, Hutchison Kent E, Filbey Francesca M

Abstract excerpt

Heavy cannabis users display smaller amygdalae and hippocampi than controls, and genetic variation accounts for a large proportion of variance in liability to cannabis dependence (CD). A single nucleotide polymorphism in the cannabis receptor-1 gene (CNR1), rs2023239, has been associated with CD diagnosis and intermediate phenotypes, including abstinence-induced withdrawal, cue-elicited craving, and...

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PMID: 22669173
DOI: 10.1038/npp.2012.92
PMCID: PMC3442352

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CNR1

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