Article
Genome-wide association study identifies a novel locus for cannabis dependence.
Molecular psychiatry - 1 May 2018
Agrawal A, Chou Y-L, Carey C E, Baranger D A A, Zhang B, Sherva R, Wetherill L, Kapoor M, Wang J-C, Bertelsen S, Anokhin A P, Hesselbrock V, Kramer J, Lynskey M T, Meyers J L, Nurnberger J I, Rice J P, Tischfield J, Bierut L J, Degenhardt L, Farrer L A, Gelernter J, Hariri A R, Heath A C, Kranzler H R, Madden P A F, Martin N G, Montgomery G W, Porjesz B, Wang T, Whitfield J B, Edenberg H J, Foroud T, Goate A M, Bogdan R, Nelson E C
Abstract excerpt
Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of genome-wide association study data on 2080 cannabis-dependent cases and 6435 cannabis-exposed controls of European descent. A cluster of correlated single-nucleotide polymorphisms (SNPs) in a novel region on chromosome 10 was genome-wide significant (lowest...
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