A genome-wide association study of DSM-IV cannabis dependence.

doi:10.1111/j.1369-1600.2010.00255.x

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Article

A genome-wide association study of DSM-IV cannabis dependence.

Addiction biology - 1 Jul 2011

Agrawal Arpana, Lynskey Michael T, Hinrichs Anthony, Grucza Richard, Saccone Scott F, Krueger Robert, Neuman Rosalind, Howells William, Fisher Sherri, Fox Louis, Cloninger Robert, Dick Danielle M, Doheny Kimberly F, Edenberg Howard J, Goate Alison M, Hesselbrock Victor, Johnson Eric, Kramer John, Kuperman Samuel, Nurnberger John I, Pugh Elizabeth, Schuckit Marc, Tischfield Jay, Rice John P, Bucholz Kathleen K, Bierut Laura J

Abstract excerpt

Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted...

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PMID: 21668797
DOI: 10.1111/j.1369-1600.2010.00255.x
PMCID: PMC3117436

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