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Article

Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.

PloS one - 1 Jan 2012

Tobi Elmar W, Slagboom P Eline, van Dongen Jenny, Kremer Dennis, Stein Aryeh D, Putter Hein, Heijmans Bastiaan T, Lumey L H

Abstract excerpt

Both the early environment and genetic variation may affect DNA methylation, which is one of the major molecular marks of the epigenome. The combined effect of these factors on a well-defined locus has not been studied to date. We evaluated the association of periconceptional exposure to the Dutch Famine of 1944-45, as an example of an early environmental exposure, and single nucleotide polymorphisms covering the...

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genomic Imprinting

Share to Insulin-Like Growth Factor II

Share to Regulatory Sequences, Nucleic Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 22666415
DOI: 10.1371/journal.pone.0037933
PMCID: PMC3364289

Genes

IGF2
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.PMID 22666415Read ↗

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