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DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults

13 Nov 2012

Abstract excerpt

BACKGROUND: The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA methylation at the IGF2/H19 locus. Postnatally, methylation at the IGF2/H19 imprinting control region (ICR) has been linked with cerebellum weight. We aimed to investigate whether decreased...

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PMID: 23148549
DOI: 10.1186/1868-7083-4-21

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