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Article

Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins.

PloS one - 1 Jan 2011

Coolen Marcel W, Statham Aaron L, Qu Wenjia, Campbell Megan J, Henders Anjali K, Montgomery Grant W, Martin Nick G, Clark Susan J

Abstract excerpt

One of the best studied read-outs of epigenetic change is the differential expression of imprinted genes, controlled by differential methylation of imprinted control regions (ICRs). To address the impact of genotype on the epigenome, we performed a detailed study in 128 pairs of monozygotic (MZ) and 128 pairs of dizygotic (DZ) twins, interrogating the DNA methylation status of the ICRs of IGF2, H19, KCNQ1, GNAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21991322
DOI: 10.1371/journal.pone.0025590
PMCID: PMC3184992

Genes

IGF2
CTCF
GNAS
KCNQ1
RUNX1

Provenance

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