Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Functional Analysis of p21Cip1/CDKN1A and Its Family Members in Trophoblastic Cells of the Placenta and Its Roles in Preeclampsia

27 Aug 2021

Abstract excerpt

Preeclampsia (PE), a gestational hypertensive disease originating from the placenta, is characterized by an imbalance of various cellular processes. The cell cycle regulator p21Cip1/CDKN1A (p21) and its family members p27 and p57 regulate signaling pathways fundamental to placental development. The aim of the present study was to enlighten the individual roles of these cell cycle regulators in placental...

Source

Identifiers

PMID: 34571867
DOI: 10.3390/cells10092214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Analysis of p21Cip1/CDKN1A and Its Family Members in Trophoblastic Cells of the Placenta and Its Roles in PreeclampsiaPMID 34571867Read ↗

Function of p21 (Cip1/Waf1/CDKN1A) in Migration and Invasion of Cancer and Trophoblastic CellsSemantic proximity Read ↗

Expression Patterns of the Cell-cycle Inhibitor p27 and the Cell-cycle Promoter Cyclin E in the Human Placenta Throughout Gestation: Implications for the Control of ProliferationSemantic proximity Read ↗

Location of cell cycle regulators cyclin B1, cyclin A, PCNA, Ki67 and cell cycle inhibitors p21, p27 and p57 in human first trimester placenta and deciduasSemantic proximity Read ↗

Attenuated estrogen signaling disrupts placentation and drives trophoblast defects in Down syndromeSemantic proximity Read ↗

The expression of cell cycle related proteins PCNA, Ki67, p27 and p57 in normal and preeclamptic human placentasSemantic proximity Read ↗

Dysregulated GLUT1 results in the pathogenesis of preeclampsia by impairing the function of trophoblast cellsSemantic proximity Read ↗

Transcriptomic profiling of trophoblast fusion using BeWo and JEG-3 cell linesSemantic proximity Read ↗

Shifting perspectives from “oncogenic” to oncofetal proteins; how these factors drive placental developmentSemantic proximity Read ↗

Urothelial Cancer Associated 1 (UCA1) and miR-193 Are Two Non-coding RNAs Involved in Trophoblast Fusion and Placental DiseasesSemantic proximity Read ↗

Immunohistochemical Expression of Cell Cycle Proteins E2F-1, Cdk-2, Cyclin E, p27kip1, and Ki-67 in Normal Placenta and Gestational Trophoblastic DiseaseSemantic proximity Read ↗

Expression of CPPED1 in human trophoblasts is associated with timing of term birth.Semantic proximity Read ↗

The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytializationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.