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Article

p53 Mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes).

Biochemical and biophysical research communications - 13 Jul 2012

Isoe Yasuko, Okuyama Teruhiro, Taniguchi Yoshihito, Kubo Takeo, Takeuchi Hideaki

Abstract excerpt

Tumor suppressor p53 negatively regulates self-renewal of neural stem cells in the adult murine brain. Here, we report that the p53 null mutation in medaka fish (Oryzias latipes) suppressed neurogenesis in the telencephalon, independent of cell death. By using 5-bromo-29-deoxyuridine (BrdU) immun...

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Source

Identifiers

PMID: 22659737
DOI: 10.1016/j.bbrc.2012.05.125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22659737-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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