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Article

Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

Molecular cell - 13 Jul 2012

Latypov Vitaly F, Tubbs Julie L, Watson Amanda J, Marriott Andrew S, McGown Gail, Thorncroft Mary, Wilkinson Oliver J, Senthong Pattama, Butt Amna, Arvai Andrew S, Millington Christopher L, Povey Andrew C, Williams David M, Santibanez-Koref Mauro F, Tainer John A, Margison Geoffrey P

Abstract excerpt

Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially elucidated. Here we demonstrate that in Schizosaccharomyces pombe a DNA recognition protein, alkyltransferase-like 1 (Atl1), can play a pivotal role in selecting a specific NER pathway, depending on the nature of the DNA modification. The relative ease of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22658721
DOI: 10.1016/j.molcel.2012.04.028
PMCID: PMC3398191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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