Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE2

31 May 2012

Abstract excerpt

Epidemiology studies and clinical trials have suggested that the use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, can significantly reduce the incidence of and mortality associated with many cancers, and upregulation of the COX2-PGE(2) pathway in tumor microenvironments might drive several aspects of cancer progression. For these reasons, the mechanisms linking COX blockade and cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Eicosanoids and Hypertension Pharmacology
Share to Inflammatory mediators and NSAID effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22658594
DOI: 10.1016/j.cub.2012.05.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE2PMID 22658594Read ↗

The wound inflammatory response exacerbates growth of pre‐neoplastic cells and progression to cancerSemantic proximity Read ↗

New insights into the functions of Cox-2 in skin and esophageal malignanciesSemantic proximity Read ↗

Telomere shortening produces an inflammatory environment that promotes tumor invasiveness in zebrafishSemantic proximity Read ↗

Role of myeloid cells and leukotriene signalling in Uveal Melanoma progressionSemantic proximity Read ↗

Oncogenic RAS drives rapid onset cellular plasticity and elicits a tumour-promoting neutrophil response at the inception of preneoplastic developmentSemantic proximity Read ↗

Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs.Semantic proximity Read ↗

Generation of a double binary transgenic zebrafish model to study myeloid gene regulation in response to melanocyte transformationSemantic proximity Read ↗

Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice.Semantic proximity Read ↗

The Adenomatous Polyposis Coli Tumor Suppressor Gene Regulates Expression of Cyclooxygenase-2 by a Mechanism That Involves Retinoic AcidSemantic proximity Read ↗

Aberrant expression of the COX2/PGE <sub>2</sub> axis is induced by activation of the RAF/MEK/ERK pathway in BRAF <sup>V595E</sup> canine urothelial carcinomaSemantic proximity Read ↗

Early Neoplastic Progression Is Complement IndependentSemantic proximity Read ↗

The role of COX-2 in intestinal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.