Article

Role of myeloid cells and leukotriene signalling in Uveal Melanoma progression

2026-03-11

Abstract excerpt

<title>Abstract</title> <p>Uveal melanoma (UM) is the most common and fatal primary intraocular malignancy in adults. Most UM patients carry activating mutations in Gαq or Gα11, alpha subunits of trimeric G-proteins associated with cysteinyl leukotriene receptors (CYSLTRs). To investigate the involvement of leukotrienes in activating CYSLTRs and their ability to induce YAP signalling, we generated four geneticall...

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Literature Corpus work: 3f9b22d1-05ce-5472-8757-f10720132b73
DOI: 10.21203/rs.3.rs-8735458/v1

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