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Article

Characterization of whole genome amplified (WGA) DNA for use in genotyping assay development.

BMC genomics - 1 Jun 2012

Han Tao, Chang Ching-Wei, Kwekel Joshua C, Chen Ying, Ge Yun, Martinez-Murillo Francisco, Roscoe Donna, Težak Zivana, Philip Reena, Bijwaard Karen, Fuscoe James C

Abstract excerpt

BACKGROUND: Genotyping assays often require substantial amounts of DNA. To overcome the problem of limiting amounts of available DNA, Whole Genome Amplification (WGA) methods have been developed. The multiple displacement amplification (MDA) method using Φ29 polymerase has become the preferred choice due to its high processivity and low error rate. However, the uniformity and fidelity of the amplification process...

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PMID: 22655855
DOI: 10.1186/1471-2164-13-217
PMCID: PMC3403925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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