Article
Detection of exonic copy-number changes using a highly efficient oligonucleotide-based comparative genomic hybridization-array method.
Human mutation - 1 Sept 2008
Saillour Yoann, Cossée Mireille, Leturcq France, Vasson Aurélie, Beugnet Caroline, Poirier Karine, Commere Virginie, Sublemontier Sébastien, Viel Marion, Letourneur Franck, Barbot Jean Claude, Deburgrave Nathalie, Chelly Jamel, Bienvenu Thierry
Abstract excerpt
Genomic copy-number variations (CNVs) involving large DNA segments are known to cause many genetic disorders. Depending on the changes, they are predicted to lead either to decreased or an increased gene expression. However, the ability to detect smaller exonic copy-number changes has not been explored. Here we describe a new oligonucleotide-based comparative genomic hybridization (CGH)-array approach for...
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