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Comparison of three whole genome amplification methods for detection of genomic aberrations in single cells

2 Jul 2016

Abstract excerpt

OBJECTIVE: Detection of genomic copy number abnormalities in a single cell using array comparative genomic hybridization (CGH) offers a promising non-invasive alternative for prenatal diagnosis. Our objective was to compare three commercially available whole-genome amplification (WGA) kits for their capacity to produce high quality DNA from single cells that is suitable for both molecular genotyping and array...

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PMID: 27368744
DOI: 10.1002/pd.4866

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