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Article

Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration.

PloS one - 1 Jan 2012

Zhu Yichao, Tian Yinhui, Du Jun, Hu Zhenzhen, Yang Ling, Liu Jiaojing, Gu Luo

Abstract excerpt

BACKGROUND: The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during development and tissue homoeostasis. However, Wnt5a signaling in breast cancer progression remains poorly defined. METHODOLOGY/PRINCIPAL FINDINGS: We showed here that Wnt5a activated Dvl2, Daam1 and RhoA, and promoted migration of breast cancer cells,...

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Identifiers

PMID: 22655072
DOI: 10.1371/journal.pone.0037823
PMCID: PMC3360006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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