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WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.

Cellular signalling - 1 Oct 2024

Zhao Huanyu, Wu Guangping, Luo Yuan, Xie Yusai, Han Yang, Zhang Di, Han Qiang, Zhao Xinran, Qin Ye, Li Qingchang, Wang Enhua

Abstract excerpt

The WNT5B ligand regulates the non-canonical wingless-related integration site (WNT)-planar cell polarity (PCP) pathway. However, the detailed mechanism underlying the activity of WNT5B in the WNT-PCP pathway in non-small cell lung cancer (NSCLC) is unclear. In this study, we assessed the clinicopathological significance of WNT5B expression in NSCLC specimens. WNT5B-overexpression and -knockdown NSCLC cell lines...

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PMID: 39094673
DOI: 10.1016/j.cellsig.2024.111330

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