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Article

Role for Daple in non‐canonical Wnt signaling during gastric cancer invasion and metastasis

18 Nov 2015

Abstract excerpt

In gastric cancer, the non-canonical Wnt signaling pathway is activated by Wnt5a, which has a critical role in disease outcome. Previous studies have shown that Wnt5a mediates the expression of the extracellular matrix protein laminin γ2 through Rac and JNK activation to promote gastric cancer progression. However, the mechanism of this regulatory pathway has not been completely addressed. The scaffold protein...

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PMID: 26577606
DOI: 10.1111/cas.12848

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