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Article

Early complex I assembly defects result in rapid turnover of the ND1 subunit.

Human molecular genetics - 1 Sept 2012

Zurita Rendón Olga, Shoubridge Eric A

Abstract excerpt

Complex I (CI, NADH ubiquinone oxidoreductase), the largest complex of the respiratory chain, is composed of 45 structural subunits, 7 of which are encoded in mtDNA. At least 10 factors necessary for holoenzyme assembly have been identified; however, the specific roles of most of them are not well understood. We investigated the role of NDUFAF3, NDUFAF4, C8orf38 and C20orf7, four early assembly factors, in the...

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Share to Electron Transport Complex I
Share to Electrophoresis, Gel, Two-Dimensional
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22653752
DOI: 10.1093/hmg/dds209
PMCID: PMC3412381

Genes

NDUFAF3
NDUFAF4
NDUFA9
NDUFAF2
NDUFS2
NDUFS3

Provenance

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