Article
Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease.
The EMBO journal - 11 Jul 2007
Dunning C J R, McKenzie M, Sugiana C, Lazarou M, Silke J, Connelly A, Fletcher J M, Kirby D M, Thorburn D R, Ryan M T
Abstract excerpt
In humans, complex I of the respiratory chain is composed of seven mitochondrial DNA (mtDNA)-encoded and 38 nuclear-encoded subunits that assemble together in a process that is poorly defined. To date, only two complex I assembly factors have been identified and how each functions is not clear. Here, we show that the human complex I assembly factor CIA30 (complex I intermediate associated protein) associates with...
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