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Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I.

Human molecular genetics - 15 May 2015

Formosa Luke E, Mimaki Masakazu, Frazier Ann E, McKenzie Matthew, Stait Tegan L, Thorburn David R, Stroud David A, Ryan Michael T

Abstract excerpt

Human mitochondrial complex I is the largest enzyme of the respiratory chain and is composed of 44 different subunits. Complex I subunits are encoded by both nuclear and mitochondrial (mt) DNA and their assembly requires a number of additional proteins. FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) was recently identified as a putative assembly factor and FOXRED1 mutations in patients cause...

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PMID: 25678554
DOI: 10.1093/hmg/ddv058

Genes

FOXRED1

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