Article
Five entry points of the mitochondrially encoded subunits in mammalian complex I assembly.
Molecular and cellular biology - 1 Jun 2010
Perales-Clemente Ester, Fernández-Vizarra Erika, Acín-Pérez Rebeca, Movilla Nieves, Bayona-Bafaluy María Pilar, Moreno-Loshuertos Raquel, Pérez-Martos Acisclo, Fernández-Silva Patricio, Enríquez José Antonio
Abstract excerpt
Complex I (CI) is the largest enzyme of the mammalian mitochondrial respiratory chain. The biogenesis of the complex is a very complex process due to its large size and number of subunits (45 subunits). The situation is further complicated due to the fact that its subunits have a double genomic origin, as seven of them are encoded by the mitochondrial DNA. Understanding of the assembly process and...
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