Article
Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients.
PloS one - 1 Jan 2012
Koide Takayoshi, Banno Masahiro, Aleksic Branko, Yamashita Saori, Kikuchi Tsutomu, Kohmura Kunihiro, Adachi Yasunori, Kawano Naoko, Kushima Itaru, Nakamura Yukako, Okada Takashi, Ikeda Masashi, Ohi Kazutaka, Yasuda Yuka, Hashimoto Ryota, Inada Toshiya, Ujike Hiroshi, Iidaka Tetsuya, Suzuki Michio, Takeda Masatoshi, Iwata Nakao, Ozaki Norio
Abstract excerpt
Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (∼1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or...
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