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Article

Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families.

Psychiatric genetics - 1 Apr 2012

Yokley Jessica L, Prasad Konasale M, Chowdari Kodavali V, Talkowski Michael E, Wood Joel, Gur Ruben C, Gur Raquel E, Almasy Laura, Nimgaonkar Vishwajit L, Pogue-Geile Michael F

Abstract excerpt

OBJECTIVES: Recent work shows promising associations between schizophrenia and polymorphisms in neuregulin-1 (NRG1) and a large literature also finds strong familial relationships between schizophrenia and cognitive deficits. Given the role of NRG1 in glutamate regulation and glutamate's effect on cognition, we hypothesized that cognitive deficits may be related to variation within NRG1, providing a possible...

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Identifiers

PMID: 22183611
DOI: 10.1097/YPG.0b013e32834f352c
PMCID: PMC3290679

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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