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Article

CNNM2 in schizophrenia: multilevel evidence of genetic susceptibility, magnesium homeostasis, neurodevelopment and cognitive dysfunction.

Neuroscience - 15 Oct 2026

Jin Yang, Zhang Lige, Yao Xiaoyi, Lv Luxian, Li Wenqiang, Song Meng

Abstract excerpt

Schizophrenia (SCZ) is a common psychiatric disorder with a complex, genetically and environmentally influenced etiology, but the specific pathogenesis remains unclear. In recent years, the SCZ susceptibility gene CNNM2 (encoding cyclin M2) located at the 10q24.32-33 locus has received widespread attention. The well-validated SCZ risk interval 10q24.32-33 harbors two independent risk variants: rs11191580 in NT5C2...

Read the complete abstract on PubMed

Topics

Schizophrenia
Animals
Humans
Homeostasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Magnesium

Cognitive Dysfunction

Neurodevelopment

Brain

Cation Transport Proteins

Source

Identifiers

PMID: 42603609
DOI: 10.1016/j.neuroscience.2026.08.022

Genes

CNNM2
NT5C2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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