Article
Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7.
DNA and cell biology - 1 Dec 1990
Gonzalez F J, Liu S Y, Kozak C A, Nebert D W
Abstract excerpt
The mammalian CYP2E1 gene encodes a cytochrome P450 enzyme that is markedly increased soon after birth. In vitro evidence suggests that the rat CYP2E1 gene is positively regulated by the transcription factor HNF-1 or a protein displaying DNA-binding properties similar to HNF-1. In contrast to newborn wild-type mice and mice heterozygous for a 1.2-centiMorgan deletion on chromosome 7, newborn mice homozygous for...
Topics
- Alleles
- Animals
- Blotting, Northern
- Blotting, Southern
- Chromosome Deletion
- Chromosome Mapping
- Cytochrome P-450 Enzyme System
- DNA
- Gene Expression Regulation
- Homozygote
- Humans