Article
Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7.
DNA and cell biology - 1 Dec 1990
Gonzalez F J, Liu S Y, Kozak C A, Nebert D W
Abstract excerpt
The mammalian CYP2E1 gene encodes a cytochrome P450 enzyme that is markedly increased soon after birth. In vitro evidence suggests that the rat CYP2E1 gene is positively regulated by the transcription factor HNF-1 or a protein displaying DNA-binding properties similar to HNF-1. In contrast to newborn wild-type mice and mice heterozygous for a 1.2-centiMorgan deletion on chromosome 7, newborn mice homozygous for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.