Article
Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.
The Journal of biological chemistry - 26 Jul 1996
Ishibashi S, Schwarz M, Frykman P K, Herz J, Russell D W
Abstract excerpt
Mice deficient in cholesterol 7alpha-hydroxylase, the rate-limiting enzyme of bile acid biosynthesis, were constructed by targeted disruption of the Cyp7 gene. The introduced mutation removed exons 3-5 of the gene and gave rise to a null allele that encoded no immunoreactive or enzymatically acti...
Topics
- Amino Acid Sequence
- Animals
- Animals, Newborn
- Cholesterol 7-alpha-Hydroxylase
- Cholic Acid
- Cholic Acids
- Diet
- Genes, Lethal
- Homozygote
- Mice
- Mice, Mutant Strains
- Microsomes
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Skin
- Vitamins
- Weight Gain