Article
[Specificity of molecular recognition in oligomerization of bacterial L-asparaginases].
Biomeditsinskaia khimiia - 1 Jan 2000
Mezentsev Iu V, Mol'nar A A, Sokolov N N, Lisitsyna V B, Shatskaia M A, Ivanov A S, Archakov A I
Abstract excerpt
Bacterial L-asparaginases, which are widely used in the antitumor therapy, act only as homotetramers, because their active sites are located at the interface between the subunits of the enzyme. Since salt bridges substantially stabilize L-asparaginase tetramers, we have supposed that oligomerization of bacterial L-asparaginase is a high-avidity process. This assumption was proved by bioinformatic and biosensoric...
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