Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants.

doi:10.1371/journal.pone.0117025

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Article

Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants.

PloS one - 1 Jan 2015

Maggi Maristella, Chiarelli Laurent R, Valentini Giovanna, Scotti Claudia

Abstract excerpt

Bacterial L-asparaginases have been used as anti-cancer drugs for over 4 decades though presenting, along with their therapeutic efficacy, several side effects due to their bacterial origin and, seemingly, to their secondary glutaminase activity. Helicobacter pylori type II L-asparaginase possesses interesting features, among which a reduced catalytic efficiency for L-GLN, compared to the drugs presently used in...

Topics

Amidohydrolases
Asparaginase
Catalytic Domain
Cell Proliferation
Genetic Engineering
Glutaminase
HL-60 Cells
Helicobacter pylori
Humans
Mutation
Recombinant Proteins
Threonine

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Identifiers

PMID: 25664771
DOI: 10.1371/journal.pone.0117025
PMCID: PMC4321988

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