Article
The thorough screening of the MUTYH gene in a large French cohort of sporadic colorectal cancers.
Genetic testing - 1 Jan 2007
Küry Sébastien, Buecher Bruno, Robiou-du-Pont Sébastien, Scoul Catherine, Colman Hélène, Lelièvre Bénédicte, Olschwang Sylviane, Le Houérou Claire, Le Neel Tanguy, Faroux Roger, Ollivry Jean, Lafraise Bernard, Chupin Louis-Dominique, Bézieau Stéphane
Abstract excerpt
The MUTYH gene encodes a key glycosylase of the base-excision repair system that is involved in maintaining genomic DNA stability against oxidative damage. Biallelic germline MUTYH mutations have been proved to greatly predispose to non-familial adenomatous polyposis (FAP) and non-hereditary non-polyposis colorectal cancer (HNPCC) familial recessive forms of colorectal cancer with multiple adenomas. To date,...
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