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Article

Investigation of the C-terminal domain of the bacterial DNA-(adenine N6)-methyltransferase CcrM.

Biochimie - 1 Dec 2015

Maier Johannes A H, Albu Razvan F, Jurkowski Tomasz P, Jeltsch Albert

Abstract excerpt

CcrM-related DNA-(adenine N6)-methyltransferases play very important roles in the biology of Caulobacter crescentus and other alpha-proteobacteria. These enzymes methylate GANTC sequences, but the molecular mechanism by which they recognize their target sequence is unknown. We carried out multiple sequence alignments and noticed that CcrM enzymes contain a conserved C-terminal domain (CTD) which is not present in...

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PMID: 26475175
DOI: 10.1016/j.biochi.2015.10.011

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