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Article

Transition from EcoDam to T4Dam DNA recognition mechanism without loss of activity and specificity.

Chembiochem : a European journal of chemical biology - 12 Oct 2009

Elsawy Hany, Podobinschi Sveatoslav, Chahar Sanjay, Jeltsch Albert

Abstract excerpt

The EcoDam and T4Dam DNA-(adenine N6)-methyltransferases both methylate the adenine residue in GATC sites. These enzymes are highly related in amino acid sequence, but they deviate in their contact to the first base pair of the target sequence. EcoDam contacts Gua1 with K9 (which corresponds to T...

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Identifiers

PMID: 19725089
DOI: 10.1002/cbic.200900441

Genes

GATC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19725089-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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