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Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

1 Jan 2019

Abstract excerpt

Abstract One of the major challenges in developing effective therapeutic strategies for Alzheimer’s disease is understanding how genetic risk factors contribute to neurodegeneration. The apolipoprotein epsilon 4 isoform (APOE4) and variants in the Clusterin (CLU) gene (also known as apolipoprotein J) are associated with increased risk of developing Alzheimer’s. Our previous work demonstrated that APOE4...

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PMID: 31853523
DOI: 10.1093/braincomms/fcz003

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