Article
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.
Genome research - 1 Oct 2012
Ha Gavin, Roth Andrew, Lai Daniel, Bashashati Ali, Ding Jiarui, Goya Rodrigo, Giuliany Ryan, Rosner Jamie, Oloumi Arusha, Shumansky Karey, Chin Suet-Feung, Turashvili Gulisa, Hirst Martin, Caldas Carlos, Marra Marco A, Aparicio Samuel, Shah Sohrab P
Abstract excerpt
Loss of heterozygosity (LOH) and copy number alteration (CNA) feature prominently in the somatic genomic landscape of tumors. As such, karyotypic aberrations in cancer genomes have been studied extensively to discover novel oncogenes and tumor-suppressor genes. Advances in sequencing technology h...
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