Article
Enhanced sensitivity to quipazine in the genetically dystonic rat (dt).
Pharmacology, biochemistry, and behavior - 1 Sept 1990
Michela V L, Stratton S E, Lorden J F
Abstract excerpt
Both normal and genetically dystonic (dt) rats show a high-frequency forepaw tremor in response to systemic administration of the serotonin (5-HT) agonist quipazine at 8 days of age. The response declines with age in normal, but not dystonic, rats. By 16 days of age and after the development of a generalized movement disorder, the dystonic rat exhibits enhanced sensitivity to the tremorogenic effects of the drug...
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