Enhanced sensitivity to quipazine in the genetically dystonic rat (dt).

doi:10.1016/0091-3057(90)90053-k

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Article

Enhanced sensitivity to quipazine in the genetically dystonic rat (dt).

Pharmacology, biochemistry, and behavior - 1 Sept 1990

Michela V L, Stratton S E, Lorden J F

Abstract excerpt

Both normal and genetically dystonic (dt) rats show a high-frequency forepaw tremor in response to systemic administration of the serotonin (5-HT) agonist quipazine at 8 days of age. The response declines with age in normal, but not dystonic, rats. By 16 days of age and after the development of a...

Topics

Aging
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Dystonia
Ketanserin
Phenotype
Quipazine
Rats
Rats, Mutant Strains
Receptors, Serotonin
Tremor

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