Article
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
Nature genetics - 27 May 2012
Dunlop Malcolm G, Dobbins Sara E, Farrington Susan Mary, Jones Angela M, Palles Claire, Whiffin Nicola, Tenesa Albert, Spain Sarah, Broderick Peter, Ooi Li-Yin, Domingo Enric, Smillie Claire, Henrion Marc, Frampton Matthew, Martin Lynn, Grimes Graeme, Gorman Maggie, Semple Colin, Ma Yusanne P, Barclay Ella, Prendergast James, Cazier Jean-Baptiste, Olver Bianca, Penegar Steven, Lubbe Steven, Chander Ian, Carvajal-Carmona Luis G, Ballereau Stephane, Lloyd Amy, Vijayakrishnan Jayaram, Zgaga Lina, Rudan Igor, Theodoratou Evropi, Starr John M, Deary Ian, Kirac Iva, Kovacević Dujo, Aaltonen Lauri A, Renkonen-Sinisalo Laura, Mecklin Jukka-Pekka, Matsuda Koichi, Nakamura Yusuke, Okada Yukinori, Gallinger Steven, Duggan David J, Conti David, Newcomb Polly, Hopper John, Jenkins Mark A, Schumacher Fredrick, Casey Graham, Easton Douglas, Shah Mitul, Pharoah Paul, Lindblom Annika, Liu Tao, Smith Christopher G, West Hannah, Cheadle Jeremy P, Midgley Rachel, Kerr David J, Campbell Harry, Tomlinson Ian P, Houlston Richard S
Abstract excerpt
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P =...