Article
New genes emerging for colorectal cancer predisposition.
World journal of gastroenterology - 28 Feb 2014
Esteban-Jurado Clara, Garre Pilar, Vila Maria, Lozano Juan José, Pristoupilova Anna, Beltrán Sergi, Abulí Anna, Muñoz Jenifer, Balaguer Francesc, Ocaña Teresa, Castells Antoni, Piqué Josep M, Carracedo Angel, Ruiz-Ponte Clara, Bessa Xavier, Andreu Montserrat, Bujanda Luis, Caldés Trinidad, Castellví-Bel Sergi
Abstract excerpt
Colorectal cancer (CRC) is one of the most frequent neoplasms and an important cause of mortality in the developed world. This cancer is caused by both genetic and environmental factors although 35% of the variation in CRC susceptibility involves inherited genetic differences. Mendelian syndromes account for about 5% of the total burden of CRC, with Lynch syndrome and familial adenomatous polyposis the most...
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