Article
Analysis of mitochondrial DNA deletions in four chambers of failing human heart: hemodynamic stress, age, and disease are important factors.
Basic research in cardiology - 1 Apr 2000
Kim U K, Kim H S, Oh B H, Lee M M, Kim S H, Chae J J, Choi H S, Choe S C, Lee C C, Park Y B
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are not only responsible for organ dysfunction due to inefficient energy production but also indicators of metabolic and functional stresses in the organ. To analyze the significance of deletion mutation in human myocardium, we screened the presence of two common deletions (7.4 kb from 8637-16084 nt, 5.0 kb from 8470-13477 nt) in four chambers using long-PCR, and using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.