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Article

Genetic heterogeneity according to age at onset in bipolar disorder: a combined positional cloning and candidate gene approach.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2012

Dizier Marie-Hélène, Etain Bruno, Lajnef Mohamed, Lathrop Mark, Grozeva Detelina, Craddock Nick, Henry Chantal, Gard Sébastien, Jamain Stéphane, Leboyer Marion, Bellivier Frank, Mathieu Flavie

Abstract excerpt

This study is the first that formally tests for genetic heterogeneity of bipolar disorder (BD) according to age at onset (AAO) sub-groups by combining positional cloning and candidate gene approaches. Our previous genome-wide linkage-scan identified five genomic regions linked to early-onset form of BD. The present study uses association analysis to test genetic heterogeneity of candidate genes located in these...

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Identifiers

PMID: 22628130
DOI: 10.1002/ajmg.b.32069

Genes

ADRB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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