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Article

Sox4 cooperates with CREB in myeloid transformation

25 May 2012

Abstract excerpt

The cAMP response element-binding protein (CREB) is a nuclear transcription factor that is critical for normal and neoplastic hematopoiesis. Previous studies have demonstrated that CREB is a proto-oncogene whose overexpression promotes cellular proliferation in hematopoietic cells. Transgenic mice that overexpress CREB in myeloid cells develop a myeloproliferative disease with splenomegaly and aberrant...

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PMID: 22627767
DOI: 10.1182/blood-2011-05-357418

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